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Article

Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture.

Scientific reports - 19 Jul 2017

Guo Ren, Xu Xinxiu, Lu Yuting, Xie Xin

Abstract excerpt

Primary hepatocytes cultured in vitro are a powerful tool to study the functions of hepatocytes and to evaluate the metabolism and toxicity of new drugs. However, in vitro culture of hepatocytes has proven to be very difficult. Ordinary culture conditions lead to dedifferentiation of hepatocytes, resulting in rapid change in cell morphology and significant reduction in specific cell functions. In the current...

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Identifiers

PMID: 28724942
DOI: 10.1038/s41598-017-06433-3
PMCID: PMC5517567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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