Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.

Experimental lung research - 1 Jan 2023

Dale Tina P, Santer Michael D, Haris Mohammed, Zuo Wei, Forsyth Nicholas R

Abstract excerpt

PURPOSE: Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale. However, minimal attention has been given to the effects of hypoxia at the cellular level. We hypothesize that a persistent progenitor cell population undergoes an aberrant differentiation process, influenced by changes in oxygen. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells
Share to Hypoxia
Share to Lung

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mucin 5AC

Share to Mucins

Share to Oxygen

Share to Pulmonary Disease, Chronic Obstructive

Share to Stem Cells

Source

Identifiers

PMID: 36656657
DOI: 10.1080/01902148.2022.2158404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.PMID 36656657Read ↗

Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitroSemantic proximity Read ↗

Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity.Semantic proximity Read ↗

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosisSemantic proximity Read ↗

Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro.Semantic proximity Read ↗

Functional Analysis of Two Distinct Bronchiolar Progenitors during Lung Injury and RepairSemantic proximity Read ↗

Characterization of side population cells from human airway epithelium.Semantic proximity Read ↗

Direct and indirect roles for β-catenin in facultative basal progenitor cell differentiation.Semantic proximity Read ↗

Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial CellsSemantic proximity Read ↗

Expansion of Cultures of Human Tracheal Epithelium with Maintenance of Differentiated Structure and FunctionSemantic proximity Read ↗

Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch-Dependent MannerSemantic proximity Read ↗

Different culture media modulate growth, heterogeneity, and senescence in human mammary epithelial cell culturesSemantic proximity Read ↗

Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.