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Ex Vivo-Generated CD36 <sup>+</sup> Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication

27 Dec 2007

Abstract excerpt

The pathogenic parvovirus B19 (B19V) has an extreme tropism for human erythroid progenitor cells. In vitro, only a few erythroid leukemic cell lines (JK-1 and KU812Ep6) or megakaryoblastoid cell lines (UT7/Epo and UT7/Epo-S1) with erythroid characteristics support B19V replication, but these cells are only semipermissive. By using recent advances in generating large numbers of human erythroid progenitor cells...

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PMID: 18160440
DOI: 10.1128/jvi.02247-07

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