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Single-Cell Meta-Analysis Uncovers the Pancreatic Endothelial Cell Transcriptomic Signature and Reveals a Key Role for NKX2-3 in PLVAP Expression

24 Oct 2024

Abstract excerpt

BACKGROUND: The pancreatic vasculature displays tissue-specific physiological and functional adaptations that support rapid insulin response by β-cells. However, the digestive enzymes have made it difficult to characterize pancreatic endothelial cells (ECs), resulting in the poor understanding of pancreatic EC specialization. METHODS: Available single-nuclei/single-cell RNA-sequencing data sets were mined to...

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PMID: 39445426
DOI: 10.1161/atvbaha.124.321781

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