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Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth

23 Oct 2024

Abstract excerpt

BACKGROUND: Cancer is the leading cause of disease-related mortality in children. Causes of leukemia, the most common form, are largely unknown. Growing evidence points to an origin in-utero, when global redistribution of DNA methylation occurs driving tissue differentiation. METHODS: Epigenome-wide DNA methylation was profiled in surrogate (blood) and target (bone marrow) tissues at birth, diagnosis, remission...

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PMID: 39443995
DOI: 10.1186/s12943-024-02118-4

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