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DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia

14 Oct 2022

Abstract excerpt

Aberrant DNA methylation constitutes a key feature of pediatric acute lymphoblastic leukemia at diagnosis, however its role as a predisposing or early contributor to leukemia development remains unknown. Here, we evaluate DNA methylation at birth in 41 leukemia-discordant monozygotic twin pairs using the Illumina EPIC array on archived neonatal blood spots to identify epigenetic variation associated with...

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PMID: 36241624
DOI: 10.1038/s41467-022-33677-z

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