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Article

Genetic and Epigenetic Characterization of a Discordant KMT2A/AFF1-Rearranged Infant Monozygotic Twin Pair.

International journal of molecular sciences - 9 Sept 2021

Russo Alessia, Viberti Clara, Mareschi Katia, Casalone Elisabetta, Guarrera Simonetta, Birolo Giovanni, Cazzaniga Giovanni, Corral Lilia, Trentin Luca, Basso Giuseppe, Fagioli Franca, Matullo Giuseppe

Abstract excerpt

The KMT2A/AFF1 rearrangement is associated with an unfavorable prognosis in infant acute lymphocytic leukemia (ALL). Discordant ALL in monozygotic twins is uncommon and represents an attractive resource to evaluate intrauterine environment-genetic interplay in ALL. Mutational and epigenetic profiles were characterized for a discordant KMT2A/AFF1-rearranged infant monozygotic twin pair and their parents, and they...

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Identifiers

PMID: 34575904
DOI: 10.3390/ijms22189740
PMCID: PMC8466096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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