Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

19 Jul 2021

Abstract excerpt

Abstract Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the modified Rodnan skin score, the most widely used clinical measure of skin disease severity. Murine fibrosis models indicate that myofibroblasts can arise from a variety of different cell types, but their origin in SSc skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to IL-33, ST2, and ILC Pathways
Share to Inflammatory Myopathies and Dermatomyositis
Share to Systemic Sclerosis and Related Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34282151
DOI: 10.1038/s41467-021-24607-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skinPMID 34282151Read ↗

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized SclerodermaSemantic proximity Read ↗

Mapping spatially-resolved transcriptomes in systemic sclerosisSemantic proximity Read ↗

Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalentsSemantic proximity Read ↗

Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosisSemantic proximity Read ↗

RNA-Seq analysis identifies novel roles for the primary cilia gene <i>SPAG17</i> and the <i>SOX9</i> locus non-coding RNAs in systemic sclerosisSemantic proximity Read ↗

Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic SclerosisSemantic proximity Read ↗

Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic SclerosisSemantic proximity Read ↗

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosisSemantic proximity Read ↗

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cellsSemantic proximity Read ↗

Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin.Semantic proximity Read ↗

Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patientsSemantic proximity Read ↗

Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.