Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin

15 Apr 2025

Abstract excerpt

Fibroblasts are central to pathogenesis of systemic sclerosis (SSc). However, studies of conventional explant fibroblast cultures incompletely reflect disease biology and treatment response. We isolated a second nonmigratory "resident" population of fibroblasts from skin biopsies after outgrowth of explant "migratory" cells. These nonmotile resident fibroblasts were compared with migratory cells from the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammatory Myopathies and Dermatomyositis
Share to Skin Diseases and Diabetes
Share to Systemic Sclerosis and Related Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40232859
DOI: 10.1172/jci.insight.185618

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skinPMID 40232859Read ↗

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized SclerodermaSemantic proximity Read ↗

Mapping spatially-resolved transcriptomes in systemic sclerosisSemantic proximity Read ↗

Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosisSemantic proximity Read ↗

Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cellsSemantic proximity Read ↗

Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalentsSemantic proximity Read ↗

Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic SclerosisSemantic proximity Read ↗

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosisSemantic proximity Read ↗

New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity Read ↗

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseasesSemantic proximity Read ↗

The contribution of mesenchymal transitions to the pathogenesis of systemic sclerosisSemantic proximity Read ↗

Macrophage heterogeneity governs the balance between fibrosis and tissue protection in systemic sclerosis.Semantic proximity Read ↗

Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.