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Spatially informed phenotyping by cyclic-in-situ-hybridisation identifies novel fibroblast populations and their pathogenic niches in systemic sclerosis

2 Jul 2025

Abstract excerpt

OBJECTIVES: Spatially nonresolved transcriptomic data identified several functionally distinct populations of fibroblasts in health and disease. However, in-depth transcriptional profiling in situ at the single-cell resolution has not been possible so far. We thus aimed to profile these populations by single-cell spatial transcriptomics using cyclic in situ hybridisation (cISH). METHODS: We studied fibroblast...

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Share to Inflammatory Myopathies and Dermatomyositis
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PMID: 40603206
DOI: 10.1016/j.ard.2025.06.002

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