Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using genetics to explore complement C5 as a druggable protein in periodontitis.

Frontiers in immunology - 1 Jan 2024

Alayash Zoheir, Baumeister Sebastian-Edgar, Holtfreter Birte, Kocher Thomas, Baurecht Hansjörg, Ehmke Benjamin, Reckelkamm Stefan Lars, Nolde Michael

Abstract excerpt

Aim: An excessively activated or dysregulated complement system has been proven to be a vital contributor to the pathogenesis of periodontitis. It has been previously hypothesized that inhibiting the activity of complement component C5 by targeting the C5a receptor is a powerful candidate for treating periodontitis. Here, we apply the drug target instrumental variable (IV) approach to investigate the therapeutic...

Topics

Join the communities discussing this publication.

Biomarkers
Complement C5
Genetic Predisposition to Disease
Genome-Wide Association Study
Interleukin-17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1beta

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39439802
DOI: 10.3389/fimmu.2024.1407431
PMCID: PMC11493656

Genes

C5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using genetics to explore complement C5 as a druggable protein in periodontitis.PMID 39439802Read ↗

Using human genetics to validate complement C3 as a drug target in periodontitisSemantic proximity Read ↗

Complement C3 as a potential drug target in periodontitis: Evidence from the cis-Mendelian randomization approach.Semantic proximity Read ↗

Genetic Susceptibility to PeriodontitisSemantic proximity Read ↗

Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.Semantic proximity Read ↗

Causal effect of chloride intracellular channel protein 5 on chronic periodontitis: A Mendelian randomization study.Semantic proximity Read ↗

Single nucleotide polymorphisms of complement component 5 and periodontitis.Semantic proximity Read ↗

Effect of interleukin-17 on periodontitis development: An instrumental variable analysis.Semantic proximity Read ↗

Downregulation of interleukin 6 signaling might reduce the risk of periodontitis: a drug target Mendelian randomization studySemantic proximity Read ↗

Association between circulating inflammatory proteins and gout: A Mendelian randomization study.Semantic proximity Read ↗

The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.Semantic proximity Read ↗

Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis.Semantic proximity Read ↗

A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.