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Article

Effect of interleukin-17 on periodontitis development: An instrumental variable analysis.

Journal of periodontology - 1 May 2023

Baumeister Sebastian-Edgar, Holtfreter Birte, Lars Reckelkamm Stefan, Hagenfeld Daniel, Kocher Thomas, Alayash Zoheir, Ehmke Benjamin, Baurecht Hansjörg, Nolde Michael

Abstract excerpt

BACKGROUND: Circulating levels of interleukin-17 (IL-17) are associated with the presence and severity of periodontitis. However, whether IL-17 is causal for disease development is unknown. We investigated the effect of genetically proxied IL-17 on periodontitis using instrumental variable analysis. METHODS: We identified 12 genetic variants from genome-wide association study (GWAS) of 7760 European descent...

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Identifiers

PMID: 36632652
DOI: 10.1002/JPER.22-0365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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