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Article

Downregulation of interleukin 6 signaling might reduce the risk of periodontitis: a drug target Mendelian randomization study

5 Jun 2023

Abstract excerpt

Aim: Interleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the development of periodontitis. While the inhibition of the IL-6 receptor using monoclonal antibodies is a well-established therapy for some diseases, so far, its potential benefit in patients with periodontitis has not been examined. We tested the association of genetically proxied downregulation of IL-6 signaling with...

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PMID: 37342352
DOI: 10.3389/fimmu.2023.1160148

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