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Peptide Sharing Between CMV and Mismatched HLA Class I Peptides Promotes Early T-Cell-Mediated Rejection After Kidney Transplantation.

HLA - 1 Oct 2024

Peereboom Emma T M, de Marco Renato, Geneugelijk Kirsten, Jairam Jasvir, Verduyn Lunel Frans M, Blok Anna J, Medina-Pestana José, Gerbase-DeLima Maria, van Zuilen Arjan D, Spierings Eric

Abstract excerpt

Cytomegalovirus (CMV) infection is related to acute rejection and graft loss after kidney transplantation, though the underlying mechanism remains largely unknown. Some CMV strains produce a peptide that is identical to a peptide sequence found in the leader peptide of specific HLA-A and -C alleles. In this retrospective study of 351 kidney transplantations, we explored whether CMV-seropositive recipients without...

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PMID: 39435970
DOI: 10.1111/tan.15719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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