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The evolutionary enhancement of genotype-phenotype linkages in the presence of multiple copies of genetic material.

Chembiochem : a European journal of chemical biology - 13 Oct 2014

Uno Keisuke, Sunami Takeshi, Ichihashi Norikazu, Kazuta Yasuaki, Matsuura Tomoaki, Yomo Tetsuya

Abstract excerpt

Genetic evolutionary mechanisms employed by protolife developed without accompanying regulatory mechanisms for the amounts of genetic material in protocells. When many copies of genetic material are present, inactive copies generated by mutations are not effectively excluded through phenotypic selection. We demonstrate a model of gene evolution initiated with different amounts of DNA inside artificial protocells....

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PMID: 25205221
DOI: 10.1002/cbic.201402299

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