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Article

Automated in vitro evolution of a translation-coupled RNA replication system in a droplet flow reactor.

Scientific reports - 8 Aug 2018

Yoshiyama Tomoaki, Ichii Tetsuo, Yomo Tetsuya, Ichihashi Norikazu

Abstract excerpt

Automation is a useful strategy to make laborious evolutionary experiments faster and easier. To date, several types of continuous flow reactors have been developed for the automated evolutionary experiments of viruses and bacteria. However, the development of a flow reactor applicable to compartmentalized in vitro self-replication systems is still a challenge. In this study, we demonstrate automated in vitro...

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Identifiers

PMID: 30089835
DOI: 10.1038/s41598-018-30374-0
PMCID: PMC6082869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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