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Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression.

Cell death & disease - 5 Aug 2022

Varela-Eirín Marta, Carpintero-Fernández Paula, Guitián-Caamaño Amanda, Varela-Vázquez Adrián, García-Yuste Alejandro, Sánchez-Temprano Agustín, Bravo-López Susana B, Yañez-Cabanas José, Fonseca Eduardo, Largo Raquel, Mobasheri Ali, Caeiro José Ramón, Mayán María D

Abstract excerpt

The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that high levels of the transmembrane protein connexin 43 (Cx43) are associated with a senescent phenotype in chondrocytes from osteoarthritic cartilage. OA has been reclassified as a musculoskeletal disease...

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Identifiers

PMID: 35931686
DOI: 10.1038/s41419-022-05089-w
PMCID: PMC9355945

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