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Epidemiology of Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma

14 Dec 2022

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is a ubiquitous virus replicating in human dermal fibroblasts. MCPyV DNA can be detected on healthy skin in 67−90% of various body sites, and intact virions are regularly shed from the skin. Infection occurs early in life, and seropositivity increases from 37 to 42% in 1- to 6-year-olds to 92% in adults. Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine...

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PMID: 36551657
DOI: 10.3390/cancers14246176

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