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High-Resolution NMR H/D Exchange of Human Superoxide Dismutase Inclusion Bodies Reveals Significant Native Features Despite Structural Heterogeneity.

Angewandte Chemie (International ed. in English) - 13 Jun 2022

Naser Dalia, Tarasca Michael V, Siebeneichler Bruna, Schaefer Anna, Deol Harmeen K, Soule Tyler G B, Almey Johnathan, Kelso Susan, Mishra Gyana G, Simon Hilary, Meiering Elizabeth M

Abstract excerpt

Protein aggregation is central to aging, disease and biotechnology. While there has been recent progress in defining structural features of cellular protein aggregates, many aspects remain unclear due to heterogeneity of aggregates presenting obstacles to characterization. Here we report high-resolution analysis of cellular inclusion bodies (IBs) of immature human superoxide dismutase (SOD1) mutants using NMR...

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PMID: 35316563
DOI: 10.1002/anie.202112645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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