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Article

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

21 Jul 2010

Abstract excerpt

Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of metabolic syndrome. Members of the sirtuin family of proteins regulate numerous physiological processes, including those involved in nutrient regulation and the promotion of longevity. However, the important role that SIRT1, the leading sirtuin family member, plays in immune response...

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PMID: 20647536
DOI: 10.1128/mcb.00657-10

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