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Article

Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation.

Cell death & disease - 18 Oct 2024

He Guozhang, Ni Yuanting, Hua Rong, Wan Huaibin, Tan Yanhui, Chen Qiwei, Xu Shaohua, Yang Yuzhong, Zhang Lijun, Shu Wei, Huang Ke-Bin, Mo Yi, Liang Hong, Chen Ming

Abstract excerpt

Latexin (LXN) is abundant in macrophages and plays critical roles in inflammation. Much is known about macrophages in atherosclerosis, the role of macrophage LXN in atherosclerosis has remained elusive. Here, the expression of LXN in human and mouse atherosclerotic lesions was examined by immunofluorescence and immunohistochemistry. LXN knockout and LXN/ApoE double-knockout mice were generated to evaluate the...

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Share to Apolipoproteins E
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Foam Cells

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 39424784
DOI: 10.1038/s41419-024-07141-3
PMCID: PMC11492231

Genes

LXN
JAK1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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