Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.

doi:10.1007/s41999-024-01080-0

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Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.

European geriatric medicine - 1 Feb 2025

Shiratsuchi Daijo, Taniguchi Yoshiaki, Kiuchi Yuto, Akaida Shoma, Makizako Hyuma

Abstract excerpt

PURPOSE: Polymorphisms (rs1815739; R577X) in the gene encoding alpha-actinin-3 (ACTN3) are thought to be associated with body composition and physical function in older people and athletes. RR homozygotes are associated with greater expression of ACTN3 protein in muscle than the X-allele carriers. We aimed to investigate the association between ACTN3 R577X polymorphism and appendicular skeletal muscle mass,...

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PMID: 39424763
DOI: 10.1007/s41999-024-01080-0
PMCID: PMC11850411

Genes

ACTN3

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