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ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study.

Age and ageing - 1 May 2018

Ma Teng, Lu Deyi, Zhu Yin-Sheng, Chu Xue-Feng, Wang Yong, Shi Guo-Ping, Wang Zheng-Dong, Yu Li, Jiang Xiao-Yan, Wang Xiao-Feng

Abstract excerpt

Objective: To examine the associations of the actinin alpha 3 gene (ACTN3) R577X polymorphism with physical performance and frailty in an older Chinese population. Methods: Data from 1,463 individuals (57.8% female) aged 70-87 years from the Rugao Longevity and Ageing Study were used. The associations between R577X and timed 5-m walk, grip strength, timed Up and Go test, and frailty index (FI) based on deficits...

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PMID: 29447359
DOI: 10.1093/ageing/afy007

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ACTN3

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