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Article

Association of the ACTN3 Genotype with Muscle Function: A Systematic Review and Meta-analysis.

International journal of sports medicine - 1 Aug 2026

Kamiya-Saito Mika, Zempo Hirofumi, de Almeida Kathleen Yasmin, Homma Hiroki, Mochizuki Yukina, Deguchi Minoru, Kozuma Ayumu, Tashiro Sora, Kikuchi Naoki

Abstract excerpt

Abstract: The R577X polymorphism in the α-actinin-3 gene (ACTN3) influences the expression of α-actinin-3, and previous studies have reported its association with muscle strength and power performance. This systematic review and meta-analysis aimed to clarify the relationship between the ACTN3 R577X polymorphism and various indicators of muscle strength and power. A systematic search of PubMed and Web of Science...

Topics

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Actinin
Athletic Performance
ACTN3 gene
Genotype
Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Strength

Polymorphism, Genetic

Source

Identifiers

PMID: 41740948
DOI: 10.1055/a-2799-1026

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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