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Article

ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2008

Walsh Sean, Liu Dongmei, Metter E Jeffrey, Ferrucci Luigi, Roth Stephen M

Abstract excerpt

The R577X polymorphism in the alpha-actinin-3 encoding gene (ACTN3) has been associated with elite athletic performance, and recently with differences in isometric and dynamic muscle strength and power in the general population. In this study we sought to determine the association of ACTN3 R577X...

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Source

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Identifiers

PMID: 18756004
DOI: 10.1152/japplphysiol.90856.2008
PMCID: PMC2584847

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18756004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.PMID 18756004Read ↗

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.Semantic proximity Read ↗

ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.Semantic proximity Read ↗

Association of the ACTN3 genotype and physical functioning with age in older adults.Semantic proximity Read ↗

ACTN3 genotype and modulation of skeletal muscle response to exercise in human subjects.Semantic proximity Read ↗

Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and diseaseSemantic proximity Read ↗

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance.Semantic proximity Read ↗

ACTN3 genotype does not influence muscle power.Semantic proximity Read ↗

ACTN3: A genetic influence on muscle function and athletic performance.Semantic proximity Read ↗

History-dependent force, angular velocity and muscular endurance in ACTN3 genotypes.Semantic proximity Read ↗

Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect.Semantic proximity Read ↗

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alpha-actinin-3 and performance.Semantic proximity Read ↗

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