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Article

ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2008

Walsh Sean, Liu Dongmei, Metter E Jeffrey, Ferrucci Luigi, Roth Stephen M

Abstract excerpt

The R577X polymorphism in the alpha-actinin-3 encoding gene (ACTN3) has been associated with elite athletic performance, and recently with differences in isometric and dynamic muscle strength and power in the general population. In this study we sought to determine the association of ACTN3 R577X genotype with muscle strength and mass phenotypes in men and women across the adult age span. Eight hundred forty-eight...

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Identifiers

PMID: 18756004
DOI: 10.1152/japplphysiol.90856.2008
PMCID: PMC2584847

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.PMID 18756004Read ↗

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.Semantic proximity Read ↗

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ACTN3 genotype and modulation of skeletal muscle response to exercise in human subjects.Semantic proximity Read ↗

Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and diseaseSemantic proximity Read ↗

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