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Article

Sex-specific physical activity thresholds influencing muscle function in older adults with XX genotype of ACTN3 R577X.

Scientific reports - 3 Sept 2026

Hsu Hsiu-Ching, Fang Wen-Hui, Lee Meng-Chang, Chen Wei-Teing, Chen Yu-Hsuan, Lin Hsiao-Ting, Wang Chih-Chien, Lin Syu-Bi, Chen Cheng-Jung, Chen Mei-Jung, Su Sui-Lung

Abstract excerpt

Physical activity is widely recommended to maintain muscle health in older adults, yet its effects may vary depending on genetic background. The ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in XX homozygotes and may influence skeletal muscle performance. We examined the association between physical activity and muscle mass and function in 682 community-dwelling adults aged ≥ 65 years who participated...

Read the complete abstract on PubMed

Topics

Humans
Actinin
Female
Aged
Genotype
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Muscle, Skeletal

Exercise

Sarcopenia

Hand Strength

Aged, 80 and over

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42686826
DOI: 10.1038/s41598-026-57340-5
PMCID: PMC13538621

Genes

ACTN3
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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