Article
Clonal hematopoiesis and lymphoma-associated mutations in hematopoietic progenitors in B-cell non-Hodgkin lymphoma.
Blood - 9 Apr 2026
Wiegand Laura, Silva Patricia, Noerenberg Daniel, Christen Friederike, Kopp Klara, Locher Benjamin Nick, Löwe Pelle, Tilgner Marlon, Altwasser Robert, Storzer Vanessa, Stein Catarina Marlene, Briest Franziska, Arends Christopher Maximilian, Frick Mareike, Ihlow Jana, Dolnik Anna, Ishaque Naveed, Keller Ulrich, Na Il-Kang, Penter Livius, Bullinger Lars, Hablesreiter Raphael, Damm Frederik
Abstract excerpt
ABSTRACT: The contribution of clonal hematopoiesis (CH) and disease-initiating precursors in B-cell non-Hodgkin lymphomas (B-NHLs) remains underexplored. Such precursors may drive clonal evolution, contributing to disease progression and relapse. Here, we systematically profiled genetic precursor lesions in 43 patients with B-NHL using complementary whole-exome, targeted, and single-cell sequencing approaches....
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