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Article

Genome-Wide Search for Nonadditive Allele Effects Identifies PSKH2 as Involved in the Variability of Factor V Activity.

Journal of the American Heart Association - 5 Nov 2024

Gendre Blandine, Martinez-Perez Angel, Kleber Marcus E, van Hylckama Vlieg Astrid, Boland Anne, Olaso Robert, Germain Marine, Munsch Gaëlle, Moissl Angela Patricia, Suchon Pierre, Souto Juan Carlos, Soria José Manuel, Deleuze Jean-François, März Winfried, Rosendaal Frits R, Sabater-Lleal Maria, Morange Pierre-Emmanuel, Trégouët David-Alexandre

Abstract excerpt

BACKGROUND: Factor V (FV) is a key molecular player in the coagulation cascade. FV plasma levels have been associated with several human diseases, including thrombosis, bleeding, and diabetic complications. So far, 2 genes have been robustly found through genome-wide association analyses to contribute to the inter-individual variability of plasma FV levels: structural F5 gene and PLXDC2. METHODS AND RESULTS: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39424413
DOI: 10.1161/JAHA.124.034943

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Genome-Wide Search for Nonadditive Allele Effects Identifies PSKH2 as Involved in the Variability of Factor V Activity.PMID 39424413Read ↗

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