Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An interactive human PROS1 variants database provides novel insights into the genetics and phenotypes of inherited protein S deficiency.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2026

Hou Zepeng, Liu Fangni, Dong Shixia, Guo Yiming, Yu Xiaowei, Ai Li-Jiezhuo, Zhang Mingshuo, Kang Jingxuan, Jiang Bo, Dong Yanyan, Zhao Meng, Pan Jiahui, Zhang Shujuan, Zhao Wenran, Wang Wei, Hao Dapeng, Shen Guomin

Abstract excerpt

BACKGROUND: The lack of an interactive PROS1 variant database has impeded efficient research on inherited protein S deficiency (PSD). OBJECTIVES: We aimed to develop an interactive PROS1 variant database for studying PSD epidemiology, genotype-phenotype correlations, and variant pathogenicity, thereby improving thrombotic risk prediction and clinical decision-making. METHODS: We constructed an interactive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Blood Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Genetic Association Studies

Share to Protein S

Share to Protein S Deficiency

Share to Risk Assessment

Share to Thrombosis

Source

Identifiers

PMID: 41967715
DOI: 10.1016/j.jtha.2026.04.004

Genes

PSD
PROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An interactive human PROS1 variants database provides novel insights into the genetics and phenotypes of inherited protein S deficiency.PMID 41967715Read ↗

Novel insights into inherited protein C deficiency from an interactive PROC variant database.Semantic proximity Read ↗

Clinical Manifestation and Mutation Spectrum of 53 Unrelated Pedigrees with Protein S Deficiency in ChinaSemantic proximity Read ↗

PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency.Semantic proximity Read ↗

Molecular diversity and thrombotic risk in protein S deficiency: The PROSIT studySemantic proximity Read ↗

Identification of novel PROS1 variants through systematic analysis of patients with suspected hereditary protein S deficiency.Semantic proximity Read ↗

Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S.Semantic proximity Read ↗

Clinical characteristics, genes identification and follow-up study of a patient with central venous thrombosis from a protein S deficiency pedigree.Semantic proximity Read ↗

Lessons from an elderly patient with pulmonary embolism caused by protein S deficiency: a case report.Semantic proximity Read ↗

Molecular basis of protein S deficiency.Semantic proximity Read ↗

Analysis of PROS1 mutations and clinical characteristics in three Chinese families with hereditary protein S deficiency.Semantic proximity Read ↗

Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.Semantic proximity Read ↗

Impact of SERPINC1 mutation on thrombotic phenotype in children with congenital antithrombin deficiency-first analysis of the International Society on Thrombosis and Haemostasis pediatric antithrombin deficiency database and biorepository.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.