Article
Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders.
Nature communications - 14 Jun 2022
Zhang Xinyuan, Lucas Anastasia M, Veturi Yogasudha, Drivas Theodore G, Bone William P, Verma Anurag, Chung Wendy K, Crosslin David, Denny Joshua C, Hebbring Scott, Jarvik Gail P, Kullo Iftikhar, Larson Eric B, Rasmussen-Torvik Laura J, Schaid Daniel J, Smoller Jordan W, Stanaway Ian B, Wei Wei-Qi, Weng Chunhua, Ritchie Marylyn D
Abstract excerpt
Clinical and epidemiological studies have shown that circulatory system diseases and nervous system disorders often co-occur in patients. However, genetic susceptibility factors shared between these disease categories remain largely unknown. Here, we characterized pleiotropy across 107 circulatory system and 40 nervous system traits using an ensemble of methods in the eMERGE Network and UK Biobank. Using a formal...
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