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coiaf: Directly estimating complexity of infection with allele frequencies

9 Jun 2023

Abstract excerpt

In malaria, individuals are often infected with different parasite strains. The complexity of infection (COI) is defined as the number of genetically distinct parasite strains in an individual. Changes in the mean COI in a population have been shown to be informative of changes in transmission intensity with a number of probabilistic likelihood and Bayesian models now developed to estimate the COI. However,...

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PMID: 37294835
DOI: 10.1371/journal.pcbi.1010247

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