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Article

RASAL2 activates RAC1 to promote triple-negative breast cancer progression

9 Nov 2014

Abstract excerpt

Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for recurrence in these individuals remains poorly understood. Here, we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional target of anti-invasive microRNA-203 and is overexpressed in a subset of triple-negative or estrogen...

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PMID: 25384218
DOI: 10.1172/jci76711

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