Article
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.
Cancer cell - 9 Sept 2013
McLaughlin Sara Koenig, Olsen Sarah Naomi, Dake Benjamin, De Raedt Thomas, Lim Elgene, Bronson Roderick Terry, Beroukhim Rameen, Polyak Kornelia, Brown Myles, Kuperwasser Charlotte, Cichowski Karen
Abstract excerpt
RAS genes are commonly mutated in cancer; however, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and ERK. Here, we report that the RasGAP gene, RASAL2, functions as a tumor and metastasis suppressor. RASAL2 is mutated or suppressed in human breast cancer, and RASAL2 ablation promotes tumor growth, progression, and metastasis in mouse models. In human breast cancer, RASAL2 loss...
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