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Article

Amyloid-β plaques disrupt axon initial segments.

Experimental neurology - 1 Jul 2016

Marin Miguel A, Ziburkus Jokubus, Jankowsky Joanna, Rasband Matthew N

Abstract excerpt

UNLABELLED: Amyloid-β (Aβ) plaques are one of the central pathologies of Alzheimer's disease (AD). Plaque formation in animal models of AD coincides with the appearance of synaptic abnormalities, aberrant neuronal excitability, and cognitive decline. Aβ plaques may disrupt neuronal excitability since they have been proposed to be synaptotoxic, to induce axonal varicosities and neurite breakage, and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27109181
DOI: 10.1016/j.expneurol.2016.04.018
PMCID: PMC4877279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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