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Article

A bioinformatics toolbox to prioritize causal genetic variants in candidate regions.

Trends in genetics : TIG - 1 Jan 2025

Šimon Martin, Čater Maša, Kunej Tanja, Morton Nicholas M, Horvat Simon

Abstract excerpt

This review addresses the significant challenge of identifying causal genetic variants within quantitative trait loci (QTLs) for complex traits and diseases. Despite progress in detecting the ever-larger number of such loci, establishing causality remains daunting. We advocate for integrating bioinformatics and multiomics analyses to streamline the prioritization of candidate genes' variants. Our case study on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39414414
DOI: 10.1016/j.tig.2024.09.007

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