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Article

The Genomic Landscape of NSCLC in Systemic Sclerosis Reveals Frequent TP53 Mutations and a Paucity of Actionable Oncogenes.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2026

Odintsov Igor, Hammer Mark M, Ricciuti Biagio, Pecci Federica, Awad Mark M, Dellaripa Paul F, Sholl Lynette M

Abstract excerpt

INTRODUCTION: Systemic sclerosis (SSc) is a chronic connective tissue disease associated with a significantly elevated and disproportionate risk of developing NSCLC, yet the underlying molecular drivers remain poorly understood. Specifically, it is unclear how these tumors fit within the established molecular paradigms of lung cancer, particularly in relation to the patient's smoking status and its associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41130409
DOI: 10.1016/j.jtho.2025.10.008

Genes

TP53
EGFR
ERBB2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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