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Article

Mutant p53 mediates survival of breast cancer cells

22 Sept 2009

Abstract excerpt

BACKGROUND: p53 is the most commonly mutated tumour-suppressor gene in human cancers. Unlike other tumour-suppressor genes, most p53 cancer mutations are missense mutations within the core domain, leading to the expression of a full-length mutant p53 protein. Accumulating evidence has indicated that p53 cancer mutants not only lose tumour suppression activity but also gain new oncogenic activities to promote...

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PMID: 19773755
DOI: 10.1038/sj.bjc.6605335

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