Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stress granules are not present in Kras mutant cancers and do not control tumor growth.

EMBO reports - 1 Nov 2024

Libert Maxime, Quiquempoix Sophie, Fain Jean S, Pyr Dit Ruys Sébastien, Haidar Malak, Wulleman Margaux, Herinckx Gaëtan, Vertommen Didier, Bouchart Christelle, Arsenijevic Tatjana, Van Laethem Jean-Luc, Jacquemin Patrick

Abstract excerpt

Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation, and the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In cancer, and particularly in the presence of oncogenic KRAS mutations, in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Proliferation

Share to Mutation

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 39390257
DOI: 10.1038/s44319-024-00284-6
PMCID: PMC11549491

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stress granules are not present in Kras mutant cancers and do not control tumor growth.PMID 39390257Read ↗

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules.Semantic proximity Read ↗

Dr. Jekyll and Mr. Hyde? Physiology and Pathology of Neuronal Stress GranulesSemantic proximity Read ↗

Stress-specific differences in assembly and composition of stress granules and related foci.Semantic proximity Read ↗

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?Semantic proximity Read ↗

Translational control of aberrant stress responses as a hallmark of cancer.Semantic proximity Read ↗

Intracellular energy controls dynamics of stress-induced ribonucleoprotein granulesSemantic proximity Read ↗

The Enigma of UV Stress Granules: Research Challenges and New PerspectivesSemantic proximity Read ↗

TSC2 is a stress granule suppressorSemantic proximity Read ↗

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.Semantic proximity Read ↗

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.Semantic proximity Read ↗

ASPL couples the assembly of stress granules with their VCP-mediated disassembly.Semantic proximity Read ↗

Biogenesis of stress granules and their role in the regulation of stress-induced male reproduction disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.