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Article

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules.

Cell - 15 Dec 2016

Grabocka Elda, Bar-Sagi Dafna

Abstract excerpt

There is growing evidence that stress-coping mechanisms represent tumor cell vulnerabilities that may function as therapeutically beneficial targets. Recent work has delineated an integrated stress adaptation mechanism that is characterized by the formation of cytoplasmic mRNA and protein foci, termed stress granules (SGs). Here, we demonstrate that SGs are markedly elevated in mutant KRAS cells following...

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Source

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Identifiers

PMID: 27984728
DOI: 10.1016/j.cell.2016.11.035
PMCID: PMC5441683

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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