Loss of function in protein Z (PROZ) is associated with increased risk of ischemic stroke in the UK Biobank.

doi:10.1016/j.jtha.2024.09.016

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Article

Loss of function in protein Z (PROZ) is associated with increased risk of ischemic stroke in the UK Biobank.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2025

Haj Amelia K, Ryu Justine, Jurgens Sean J, Chaudhry Sharjeel, Koyama Satoshi, Wang Xin, Choi Seung Hoan, Hou Cody, Sanna-Cherchi Simone, Anderson Christopher D, Ellinor Patrick T, Bendapudi Pavan K

Abstract excerpt

BACKGROUND: The vitamin K-dependent coagulation factor protein Z (PZ), encoded by the PROZ gene, is canonically considered to have anticoagulant effects through negative regulation of factor Xa. Paradoxically, higher circulating PZ concentrations have repeatedly been associated with an elevated risk of acute ischemic stroke. OBJECTIVES: We performed a large-scale genetic association study to examine the...

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