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Article

Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults.

Thrombosis and haemostasis - 5 Jan 2017

Zhang Lili, Segal Alan Z, Leifer Dana, Silverstein Roy L, Gerber Linda M, Devereux Richard B, Kizer Jorge R

Abstract excerpt

Protein Z (PZ) is a vitamin K-dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischaemic stroke. Although PZ-lowering gene variants have been found to be less common in ischaemic stroke, the relationship remains unclear. We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in...

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Identifiers

PMID: 27683756
DOI: 10.1160/TH16-04-0277
PMCID: PMC5798600

Genes

PROZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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