Article
[Embryonic genome organization after fertilization in mammals].
Biologie aujourd'hui - 1 Jan 2010
Beaujean Nathalie, Mason Karlla, Bonnet-Garnier Amélie, Salvaing Juliette, Debey Pascale
Abstract excerpt
In mammals, the embryonic genome is first transcriptionally inactive after fertilization. Embryonic development is then strictly dependent on the maternally inherited RNA and proteins accumulated before ovulation and present in the oocyte cytoplasm. The onset of embryonic gene expression is initiated later during development, i.e. during the "embryonic genome activation (EGA)". EGA takes place at various...
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