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Article

Detection of Germline Variants in Patients With Localized and Metastatic Prostate Cancer Through Guideline-Based Testing.

Urology practice - 1 Jan 2025

Abusamra Sophia M, Solorzano Marissa A, Quarles Jake, Luke Mallory, Patel Milan, Vince Randy, Jiang Ralph, Volin Joshua, Jacobs Michelle F, Kaffenberger Samuel D, Salami Simpa S, Palmbos Phillip, Caram Megan E V, Hollenbeck Brent K, Palapattu Ganesh S, Merajver Sofia D, Stoffel Elena M, Hafron Jason, Morgan Todd M, Reichert Zachery R

Abstract excerpt

INTRODUCTION: There is increasing awareness that patients with prostate cancer frequently harbor germline variants that may carry important implications for them and their family members. Given the variable clinical guidelines, there remains a need to better understand which patients with prostate cancer are likely to harbor pathogenic or likely pathogenic (P/LP) germline variants. We sought to understand factors...

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Source

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Identifiers

PMID: 39383006
DOI: 10.1097/UPJ.0000000000000727
PMCID: PMC11658803

Genes

ATM
BRCA2
CHEK2
HOXB13

Provenance

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