Article
Germline genetics of prostate cancer.
The Prostate - 1 Aug 2022
Khan Hiba M, Cheng Heather H
Abstract excerpt
BACKGROUND: An important fraction (>/~10%) of men with high-risk, localized prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and likely pathogenic variants (also known as mutations) in DNA repair genes. These can represent known or suspected autosomal dominant cancer predisposition syndromes. Growing evidence suggests that pathogenic variants in key genes involved in homologous...
Topics
- Early Detection of Cancer
- Genetic Predisposition to Disease
- Germ Cells
- Germ-Line Mutation
- Humans
- Male
- Prostate-Specific Antigen
- Prostatic Neoplasms