Article
Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nature communications - 13 Sept 2016
Li Faxiang, Xie Xingqiao, Wang Yingli, Liu Jianping, Cheng Xiaofang, Guo Yujiao, Gong Yukang, Hu Shichen, Pan Lifeng
Abstract excerpt
Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin and TBK1 are both associated with neurodegenerative diseases. However, the mechanistic basis underlying the specific interaction between optineurin and TBK1 is still elusive. Here we determine the crystal structures of optineurin/TBK1 complex and...
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