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Article

Conformational stabilization of optineurin by the dynamic interaction of linear polyubiquitin.

Biochemical and biophysical research communications - 25 Jun 2021

Kitamura Akira, Numazawa Rika, Kinjo Masataka

Abstract excerpt

Optineurin produces intracellular multi-functions involving autophagy, vesicular trafficking, and negative regulation of inflammation signaling through interaction with various proteins such as ATG8/LC3, Rab8, and polyubiquitin. Optineurin is a component of cytoplasmic inclusion bodies (IBs) in motor neurons from amyotrophic lateral sclerosis (ALS), and its mutation E478G, has been identified in patients with...

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Identifiers

PMID: 33951500
DOI: 10.1016/j.bbrc.2021.04.103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational stabilization of optineurin by the dynamic interaction of linear polyubiquitin.PMID 33951500Read ↗

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