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Article

Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.

Autophagy - 1 Jan 2018

Li Faxiang, Xu Daichao, Wang Yingli, Zhou Zixuan, Liu Jianping, Hu Shichen, Gong Yukang, Yuan Junying, Pan Lifeng

Abstract excerpt

OPTN (optineurin), a ubiquitin-binding scaffold protein, functions as an important macroautophagy/autophagy receptor in selective autophagy processes. Mutations in OPTN have been linked with human neurodegenerative diseases including ALS and glaucoma. However, the mechanistic basis underlying the recognition of ubiquitin by OPTN and its regulation by TBK1-mediated phosphorylation are still elusive. Here, we...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29394115
DOI: 10.1080/15548627.2017.1391970
PMCID: PMC5846504

Genes

OPTN
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.PMID 29394115Read ↗

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