Article

Targeting the DNA damage response protein ATR kinase in pancreatic cancer

2020-01-01

Abstract excerpt

Therapeutic targeting of the DNA damage response (DDR), coupled with the implementation of personalised treatment strategies, has the potential to improve the poor survival outcomes of pancreatic ductal adenocarcinoma (PDAC). Many common genetic alterations in PDAC augment replication-associated DNA damage, or replication stress (RS), which increases reliance on the RS-response factor, Ataxia Telangiectasia and Ra...

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Literature Corpus work: 6695674e-351f-5454-877e-3c133ad1ae4a
DOI: 10.17863/cam.62227

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