Causal relationships between Alzheimer's disease and metabolic dysfunction associated with fatty liver disease: insights from bidirectional network Mendelian Randomization analysis.

doi:10.1007/s11306-024-02193-0

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Article

Causal relationships between Alzheimer's disease and metabolic dysfunction associated with fatty liver disease: insights from bidirectional network Mendelian Randomization analysis.

Metabolomics : Official journal of the Metabolomic Society - 13 Dec 2024

Liu Lei, Zhou Ming, Zhang Yuanyuan, Chen Yang, Wang Huiru, Cao Yuan, Fang Chao, Wan Xiaoju, Wang Xiaochen, Liu Huilan, Wang Peng

Abstract excerpt

INTRODUCTION/OBJECTIVES: Several observational investigations have observed the possible links between Alzheimer's disease (AD) and metabolic dysfunction associated with fatty liver disease (MAFLD), yet the underlying causal relationships remain undetermined. This study aimed to systemically infer the causal associations between AD and MAFLD by employing a bidirectional network two-sample Mendelian randomization...

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PMID: 39673021
DOI: 10.1007/s11306-024-02193-0

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