Article
Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis.
Translational psychiatry - 12 May 2020
Zhang Xiaoyu, Tian Qiuyue, Liu Di, Geng Tao, Xu Xizhu, Ge Siqi, Zheng Deqiang, Wu Lijuan, Song Manshu, Hou Haifeng, Wang Wei, Wang Youxin
Abstract excerpt
Prospective studies have shown that abnormally circulating cholesterol is associated with the risk of dementia. However, whether the association is causal or not remains unclear. We attempt to infer the causal association in a MR meta-analysis by using ApoE gene polymorphisms as instrument variables. Studies with dementia risk (27 studies) or circulating lipid levels (7 studies) were included, with totally 3136...
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